KCC2 Activation
Added 2020-07-26 17:57:30 +0000 UTCKCC2 is a neuron-specific membrane protein expressed throughout the central nervous system, including the hippocampus, hypothalamus, brainstem, and motoneurons of the ventral spinal cord.
Peripheral neuropathic pain, typified by the development of spontaneous pain or pain hypersensitivity following injury to the peripheral nervous system, is common, greatly impairs quality of life, and is inadequately treated with available drugs. Maladaptive changes in chloride homeostasis due to a decrease in the functional expression of the potassium-chloride cotransporter KCC2 in spinal cord dorsal horn neurons are a major contributor to the central disinhibition of γ-aminobutyric acid type A receptor– and glycine receptor–mediated signaling that characterizes neuropathic pain. A compelling novel analgesic strategy is to restore spinal ionotropic inhibition by enhancing KCC2-mediated chloride extrusion.
Which means it helps to try to restore feeling/movement to damaged nerve areas.
Comments
beautiful music, great content! tysm <3
Livier
2021-07-16 22:14:20 +0000 UTCanalgesic effect is parmanent?temporary?
2021-05-17 13:54:58 +0000 UTCHas this helped you ?
2021-01-04 09:03:18 +0000 UTCIf you have chronic pain, give this a try. It’s beautiful to listen to as well. Thank you.
2020-12-10 08:27:00 +0000 UTCDisc bulges causes me so much pain in my back and legs, I am in 20s, an artist, it is difficult to even sit for sometime without pain, really hope this helps as it is for peripheral nerves🙏
2020-09-06 03:21:19 +0000 UTCHow many times a day? Can we loop it while we sleep?
Geust24
2020-08-02 13:32:50 +0000 UTCYeah it will because it mentions glands in the brain
pseudonym
2020-07-28 14:57:37 +0000 UTCWell if it's unusual then it is most likely necessary. Come on man don't complain. Just use it.
pseudonym
2020-07-28 14:57:09 +0000 UTCYour new videos are more like 4 minutes, why is this 25mins long ?
Moritz Alexander
2020-07-27 08:20:14 +0000 UTCdoes this also raise KCC2 in the brain?
2020-07-26 23:14:42 +0000 UTCOooooooh I hope this will do what I think it will!
Kat
2020-07-26 20:52:02 +0000 UTC
