Anytime I approach hands I have a set shape in mind that I tend to adhere to. There are a lot of features in both a hand and paw, and blending them becomes fun when you start choosing what to add/remove from each. For these sets I edited features like pawpads, additional fur, number of digits, and claw shape.
Creases, such as the heart line and thumb joint, can help clarify orientation and can be used to exaggerate the quality of the skin.