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Separation of chlorotoluene isomers (para and ortho) 2nd step in making Pyrimethamine

Separation of chlorotoluene isomers (para and ortho) 2nd step in making Pyrimethamine

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Wow, this one had a lot of new stuff for me. Thank you! 2 questions: - Is there some sort of reasonable formula to calculate the length of a column needed to distill 2 components, or is that a deceptively complicated question? - Is there any way you could demonstrate your progress on the path to synthesizing the pyrimethamine? If you could show a sort of roadmap at the end of the videos that demonstrated where you are along the process, I really think that would be delightful. Bonus question: Would you have an interest in more toluene? I only needed a few ounces for the sake of thinning a polysiloxane used for spraypainting silicone prosthetics, but the only place I could find it made me buy a whole gallon (industrial grade). (That's probably an over-complicated question, because I don't know the first thing about shipping hazmat materials.)

Paul Grodt


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