This probiotic strain attenuates symptoms of autism , Obsessive compulsive disorder and depression

When we think about micro organisms like parasites and bad bacteria, we can clearly see examples of these ‘bad bugs’ altering human behavior in negative ways.

In a pathological context, we know that parasites like toxoplasma gondii can infect many warm-blooded animals, including cats and humans. In cats, which are its definitive hosts, it completes its sexual reproduction cycle. When it infects intermediate hosts, such as rodents, the parasite manipulates their behavior, making them less fearful of predators, including cats. This aids in the parasite's life cycle by increasing the likelihood that it infevts rodents that will be be eaten by cats, thus allowing the parasite to return to its definitive host.

Toxoplasma is known to produce an enzyme called tyrosine hydroxylase, which is involved in the synthesis of dopamine. Elevated dopamine levels can alter behavior and reduce fear response. In humans, infection with toxoplasmosis can have subtle effects on behavior and personality. Some studies suggest that infected individuals can exhibit increased risk-taking behaviors

These are examples of bad bugs altering human and animal behavior in negative ways. But are there ‘good’ bacteria that can alter human behavior in positive ways? Could some of these bacteria be used to treat psychological disorders like ASD, anxiety, depression and OCD?

Psychobiotics for autism?

Lactobacillus plantarum PS128 is a specific probiotic strain (gut bacteria) that has gained interest in recent years for its potential therapeutic benefits in managing symptoms associated with autism spectrum disorder. It's also shown some benefits on OCD, depression and social anxiety as well in preclinical models

One of the distinguishing features of PS128 is its ability to survive the acidic environment of the stomach and the presence of bile in the intestines, which allows it to reach the gut alive and in sufficient numbers to exert its effects. This is very similar to how spores works. It has demonstrated strong adherence to intestinal cells and has been shown to have a beneficial effect on the overall gut microbiota composition as well. Meaning it can help promote the overall health and diversity of the gut in addition to some of its specific benefits for ASD and other neurological conditions

The mechanisms by which PS128 may exert its effects are multifaceted, and similar to some of the other psycobiotics I’ve talked about. this strain may help modulate the gut-brain axis, a bidirectionan communication system between the central nervous system and the gastrointestinal tract. One of the key ways ps128 might influence the gut-brain axis is through the production of neuroactive substances such as GABA which is an inhibitory neurotransmitter that can exert calming effects on the brain. Additionally, it may help reduce inflammation by modulating immune responses, as well as influence the integrity of the gut barrier, which can prevent harmful substances (leaky gut) from entering the bloodstream and triggering immune reactions.

ASD is a complex neurodevelopmental disorder characterized by difficulties in social interaction, communication challenges, and a tendency to engage in repetitive behaviors. The etiology of ASD is not fully understood, but it is thought to involve a combination of genetic and environmental factors, including potential disturbances in the gut microbiome. New research suggests that the gut microbiome may play a role in the development and manifestation of ASD symptoms. Altered gut microbiota has been observed in virtually all individuals with ASD, and these changes in the gut ecosystem WILL affect the gut brain axis and contribute to the symptoms associated with the disorder. Preliminary research, including animal studies and small-scale human trials, has

shown good results with PS. E.g mice models of ASD treated wit PS128 exhibited improved behaviors, such as reduced anxiety and THE repetitive actions often associated with the condition. In human studies, supplementation with this strain has had similar outcomes in addition to improve barrier function.

From my own personal experience, I’ve seen this strain benefit a lot of clients I’ve worked with who suffer from OCD, compulsive behavior and social anxiety. While I haven’t personally worked with any autistic clients, I think many of the aforementioned mechansims of this strain could greatly benefit individuals with other psychiatric disorders that do not fall under the typical category of ASD.

While this strain is offend advertised as a product for individuals with autism, I think it’s application is much broader and likely very similar to some of the psychobiotic strains I’ve mentioned featured in products like the Just Calm (bifidobacterium longum).

experimental/research application: 1 serving daily on an empty stomach. If you’re taking the Just Thrive, it may be good to seperate these by 6-8 hours similar to the recommendation for Just Calm

https://benedlife.com/?s=s-l-f