Some artist notes (and whining):
Portal Pants went through few refinements, though it was mostly about building the scene and learning to use Clip Studio for lining.
Clip Studio also doesn't seem to have a good "copy selection" or "copy image to clipboard" function, mostly relying on Windows having the feature, I guess. It's an annoyance, but it does mean I'm forced to save progress to files directly. Win-win...?
By far, it's way cleaner and easier to use the pen in Clip. However, lining is still pretty time consuming, and I don't feel I get the right energy out of my sketches when I line them. That might just be a personal take, though.