The first LSD synthesis video? A response.
Added 2025-06-09 03:39:07 +0000 UTCLate last year mushroom educator Willy Myco released one of the strangest and most provocative chemistry videos I've ever seen, an apparent LSD synthesis tutorial filmed in Pakistan. Despite the video's ambitions—it reportedly cost $100,000 to produce—I strongly suspect that no LSD was synthesized, due to what appear to be fatal procedural and stoichiometric errors. I do not think this attempt was fraudulent, I strongly suspect it is real, which is what makes the video so interesting. I go through the chemistry in Willy Myco's video step by step and provide my reaction to what I think will and won't work. I hope this is educational and prevents anyone from harming vulnerable lysergamide molecules.
EDIT: I found a couple of preps that do use activated carbon during lysergic acid purification, I would still advise caution using it.
EDIT2: An extremely obvious issue that I didn't point out is that beyond LSD freebase not being blue, it's not a liquid. LSD base is a crystalline solid with a melting point around 80-85ºC, but a narrower range of 82-83ºC has also been reported. Hofmann's exact description was, "Recrystallization from benzene yielded pointed prisms with a melting point of 80-85°"
Original LSD synthesis tutorial video from Willy Myco
Willy Myco Just Released the First-Ever Video Demonstrating How to Synthesize LSD
Journal of Visualized Experiments
Comments
Peer reviewed like a boss 🔥🔥🔥
Adrian Mendez
2025-12-19 13:03:14 +0000 UTCWell I'm glad I didn't join his Patreon just to see the video. I was tempted when it came out. Some great info in your response Hamilton, thanks for your attention to detail!
Dave Wright
2025-11-13 19:02:41 +0000 UTCYou should make a reaction video
David Jennings
2025-11-09 04:05:10 +0000 UTCWilly just got scammed 100k.
brandon ells
2025-11-05 06:11:17 +0000 UTCThanks for the pdfs too, Hamilton
Geof Sawaya
2025-10-22 18:44:56 +0000 UTCAlso have you personally felt a difference between ET and LAME synths ? I feel like most wouldn’t, but “heads”, who don’t seem to be regurgitating old head stuff, tend to notice even if there is no information prior (or looking at the raw crystal)
Neemo
2025-10-09 14:57:48 +0000 UTCSorry if I missed this here, have you ever commented on the quality of synthesis videos on breaking bad forum?
Neemo
2025-10-09 14:53:59 +0000 UTCThis is like jesse making meth vs walter white
Christopher Laudate
2025-09-29 16:43:46 +0000 UTCIs that festers book on the bottom shelf? That's cool
Ed Dragan
2025-08-20 11:50:00 +0000 UTC"now you guys wanna" I don't think I can stand to hear it one more time 🤯
shawn carey
2025-07-31 14:47:57 +0000 UTCI
Malcolm Wells
2025-07-08 22:58:39 +0000 UTCCalling them "pulls" is a clear sign that this guy attended the university of BlueLight or Erowid. Pulls is a term most often used to describe the process of extracting alkaloids from a plant material like DMT from mimosa hostilis
Cheminterested
2025-06-28 16:35:55 +0000 UTCThis is a perfect example of the difference between a "cook" who thinks you can just follow a "recipe" and a chemist who understands the mechanism and is able to think dynamically about the process and make decisions based on what they are seeing. Willy Myco sucks for many reasonss
Cheminterested
2025-06-28 16:31:31 +0000 UTCI appreciate Hamilton's approach and him not wanting to seem like a hater, but I can tell you know one in the mushroom community who actually knows anything has any respect for this guy. He is a clown
Cheminterested
2025-06-26 20:17:12 +0000 UTCHEY YOU GUYS!!!!! we're making acid
Cheminterested
2025-06-26 19:07:06 +0000 UTCdepending on the lighting gray could look blue
Johnathan Mercer
2025-06-19 22:58:29 +0000 UTCthis was linguistically fascinating. verbal chemistry, if "you guys" will.
Stephen Marsh
2025-06-19 03:40:59 +0000 UTC
