In this episode I describe my own impressions on the multibillion dollar industry that has emerged around the new-ish opioid 7-hydroxymitragynine and speak with two industry insiders, Soren Shade who works as a kratom leaf vendor and policy reformer and Dr. Ahmed Alford who has studied the chemistry and pharmacology of natural Kratom alkaloids and their synthetic derivatives and has worked with the 7-hydroxymitragynine grey market.
Hamilton ascends the Carpathian Mountains, microscope in hand, to learn how Europeans use Amanita muscaria, and uncovers the chemistry behind a mushroom-inspired pharmaceutical.
2025-12-22 22:23:47 +0000 UTC View PostIn this episode I sit down with a self-taught legend of underground MDMA synthesis and former Hive member named MethylMan. We discuss Wacker oxidation, reductive amination, aluminum amalgamation and the joys and dangers of underground chemistry.
Methyl Man's Reductive Amination of MDP2P with Al/Hg + Nitromethane
The bufotenine episode from season three.
2025-12-06 03:05:27 +0000 UTC View PostIn this episode I talk with tobacco researcher Patrick Phillips about his new book "Tobacco of the Emperor" which investigates the history of Japanese cigarettes and other tobacco products. We discuss historical claims of etorphine-laced cigarettes, the opium wars, and the curiously under-researched (at least in English?) claim that millions of Chinese people were tricked into opiate addition with opium-laced Golden Bat cigarettes.
Patrick Phillips is a tobacco researcher and militaria ...
2025-11-30 19:24:22 +0000 UTC View PostIn this episode I talk with tobacco researcher Patrick Phillips about his new book "Tobacco of the Emperor" which investigates the history of Japanese cigarettes and other tobacco products. We discuss historical claims of etorphine-laced cigarettes, the opium wars, and the curiously under-researched (at least in English?) claim that millions of Chinese people were tricked into opiate addition with opium-laced Golden Bat cigarettes.
Patrick Phillips is a tobacco researcher and militaria...
2025-11-30 05:51:27 +0000 UTC View PostIn this episode I talk with MAPS phase III trial participant Becca Kacanda about her experience successfully treating PTSD with MDMA psychotherapy. The conversation covers the complexity of psychedelic psychotherapy, the importance of listening to the participants directly, and what it was like to be manipulated by Psymposia-associate Sasha Sisko who attempted to convince her that the therapy she had received was "whack-a-doodle nonsense ‘therapy.'" We also discuss her involvement with diff...
2025-11-22 21:20:49 +0000 UTC View PostIn this episode I talk with MAPS phase III trial participant Becca Kacanda about her experience successfully treating PTSD with MDMA psychotherapy. The conversation covers the complexity of psychedelic psychotherapy, the importance of listening to the participants directly, and what it was like to be manipulated by Psymposia-associate Sasha Sisko who attempted to convince her that the therapy she had received was "whack-a-doodle nonsense ‘therapy.'" We also discuss her involvement with diff...
2025-11-20 07:54:36 +0000 UTC View PostIn this episode I sit down with Cannabis researcher, grower, and entrepreneur Joel Stanley to learn about the massive shift in public perception of Cannabis that occurred after the therapeutic effect of CBD on pediatric epilepsy was recognized. We also discuss legal and regulatory changes in Cannabis, the entourage effect, development of botanical medicines, the supplement industry, and his new psychedelic venture Ajna bio...
2025-11-09 21:04:44 +0000 UTC View PostIn this episode I sit down with Cannabis researcher, grower, and entrepreneur Joel Stanley to learn about the massive shift in public perception of Cannabis that occurred after the therapeutic effect of CBD on pediatric epilepsy was recognized. We also discuss legal and regulatory changes in Cannabis, the entourage effect, development of botanical medicines, the supplement industry, and his new psychedelic venture A...
2025-11-09 07:00:20 +0000 UTC View PostPlease enjoy the ibogaine episode from season three
2025-10-28 00:41:07 +0000 UTC View PostThis is a great and far-ranging discussion with chemist and neuroscientist Dr. Andrew Gallimore about his continuous DMT infusion project (DMTx) and his new book Death by Astonishment.
Andrew's website:
www.buildingalienworlds.com
Noonautics website:
2025-10-24 21:09:02 +0000 UTC
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This is a great and far-ranging discussion with chemist and neuroscientist Dr. Andrew Gallimore about his continuous DMT infusion project (DMTx) and his new book Death by Astonishment.
Andrew Gallimore's website:
www.buildingalienworlds.com
Noonautics website:
2025-10-24 18:55:31 +0000 UTC
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Hello everybody, the subscriber Q&A returns!
Record audio of yourself asking a question (the question recording can be no more than 30 seconds) and email it to the podcast at hamiltonsresearch@gmail.com with the subject "October 2025 Q&A" followed by your Patreon username (or email address associated with the account) and your Patreon subscriber tier. Approximately 6 questions will be ans...
2025-10-21 21:18:08 +0000 UTC View PostPlease enjoy the Synthetic Toad Venom Machine episode from season three, part one from season two will be uploaded soon.
2025-10-20 16:46:21 +0000 UTC View PostPlease enjoy the Ultra-LSD episode from season three
2025-10-15 06:25:28 +0000 UTC View PostPlease enjoy the methamphetamine episode from season three
2025-10-12 21:51:33 +0000 UTC View PostIn this episode I sat down with chemistry educator and pseudoscience debunker Dave Farina of the popular YouTube channel Professor Dave explains. We discuss the threat of disinformation, how to promote truth while reducing radicalization and polarization, wokescold-edgelord dialectics, and the rhetoric of pOwning with facts and logic.
NOTE: The video is having an issue processing, give it a minute
2025-10-10 21:44:15 +0000 UTC View PostIn this episode I sat down with chemistry educator and pseudoscience debunker Dave Farina of the popular YouTube channel Professor Dave explains. We discuss the threat of disinformation, how to promote truth while reducing radicalization and polarization, wokescold-edgelord dialectics, and the rhetoric of pOwning with facts and logic.
In this episode I talk with DMTx test subject and psychonaut Carl Hayden Smith about his experience as a participant in Dr. Chris Timmermann's DMT infusion research at Imperial College London. The headier implications of alternate realities are explored more than I anticipated. This episode will be followed by an interview I recorded with Andrew Gallimore discussing his perspective on the research as well as his new book. Enjoy!
A few patrons requested I upload all the episodes of Hamilton's Pharmacopeia. I don't want to overwhelm the feed with episodes or make patrons feel spammed with notifications about new uploads so I will turn off notifications on these and try to upload at least one a week. Please enjoy this episode from season three. I may edit these to include supporting documents for anyone interested in reading more about xenon.
2025-09-18 07:50:44 +0000 UTC View Post
In this interview with Dr. Rick Doblin (almost one year after the last interview) we discuss the recent release of the (formerly) private letter the FDA sent to Lykos after the rejection of MDMA, which provides some additional insight into the FDA's motivations for rejecting MDMA as well as the role that Psymposia played. We also discuss the ongoing threats I'm receiving from Sarlo lawyers (attached) the very same people who funded Psymposia.
This interview is mostly video but the begin...
2025-09-07 02:29:30 +0000 UTC View PostLast fall, The Shulgin Foundation invited me to film the synthesis of some compounds in Alexander Shulgin's lab in an effort to teach the public about about Shulgin's chemistry. Over two days I filmed the synthesis of ariadne and DiPT (still unfinished) and made this short doc about the experience. The final proton NMR is posted after the end credits, yield of the recrystallized HCl salt was about 80%. I plan to reupload with some adjustments to the sound mix (and possibly update the diagrams...
2025-08-20 20:26:07 +0000 UTC View Post
In this episode I visit the home of MAPS founder and president of Dr. Rick Doblin to discuss the FDA's rejection of MDMA and the future of the drug's medical development.
John Semley reports for Wired on Psymposia's secret source of funding
The sex crimes and stalking of Psymposia colleague Sasha Sisko aka Erik Ahlbrand
I have attached a partially redacted docu...
2025-08-04 18:12:08 +0000 UTC View PostIn this episode I interview Dr. Panaccione, Professor of Plant and Soil Sciences at WVU Davis, about a newly discovered lysergamide producing fungus his student Corinne Hazel isolated from morning glory seeds and gave the wonderful name Periglandula clandestina. Additionally we discuss a fungus that was found on a sample of a nitropropene in Shulgin's lab (currently being cultured by Alan Rockefeller), indole diterpenes, the kykeon, and the role of psychoactive alkaloids in soil ecology. 2025-07-14 00:41:01 +0000 UTC View Post
Late last year mushroom educator Willy Myco released one of the strangest and most provocative chemistry videos I've ever seen, an apparent LSD synthesis tutorial filmed in Pakistan. Despite the video's ambitions—it reportedly cost $100,000 to produce—I strongly suspect that no LSD was synthesized, due to what appear to be fatal procedural and stoichiometric errors. I do not think this attempt was fraudulent, I strongly suspect it is real, which is what makes the video so interesting. I g...
2025-06-09 03:39:07 +0000 UTC View Post
In this episode I spend three hours talking with the ex-hacker, anti-snitching activist, and NMDA-antagonist aficionado Stephen Watt about his experience writing computer code while high on ketamine that was used to steal millions of dollars from the cinnamon apple purveying buffet chain Boston Market, as well as T.J. Maxx and Dave & Buster's. Watt analyzes the benefits and dangers of ketamine, what dangers it might pose for users like Elon Musk, and the fringe possibility that ketamine m...
2025-06-01 04:07:24 +0000 UTC View PostIn this interview I talk with former Cybin chemist and pharmacologist Dr. Josh Hartsel about his work exploring the serotonergic structure-activity relationship of novel sulfur and selenium containing phenethylamines, his work represents the first psychedelic selenium chemistry since Shulgin's 2C-Se synthesis in PiHKAL. Read his paper and enjoy our talk!
Fenderson5555 predicts 2C-T-TFM
2025-04-29 22:53:29 +0000 UTC View PostHamilton is in Spain filming a three week attempt to introduce a tellurium atom into a psychedelic molecule, he planned on releasing an interview today with Dr. Josh Hartsel but a multinational municipality issue (possibly a cyber attack?) left all of Spain without electricity, internet, or phone service. I spoke with him today at 4:00AM his time and he said the power had gone out in the middle of a 23 gram LiAlH4 nitrostyrene reduction and that he has no magnetic stirring, and that he had on...
2025-04-29 04:37:39 +0000 UTC View PostIn this episode I visit the Brooklyn home of Caveh Zahedi, director of the films "I Am a Sex Addict" and "The Sheik and I" and talk about moralism, filmmaking, his series The Show About the Show, the courage to look bad, and Jonathan Richman.
2025-04-01 19:21:59 +0000 UTC View Post