Instagram Q&A 2/23/2025

Q: Any idea on how to handle marcons in the nose?

A: Been meaning to write a patreon article on this. Thanks for the reminder lol! Theres honestly lots of things, and mold exposure + immune suppression are two big components of MARCONS. which for those unfamiliar, is a antibiotic resistant staph in the nose. One really interesting thing about MARCONS is its ability to lower a-MSH levels. That reduction occurs because the bacteria produces exotoxins that cleave a-MSH, rendering it inactive. Consequently, lower levels of a-MSH lead to increased cytokine production. But MSH is also important for treating and preventing MARCONS because it directly regulates the immune system and actually prevents MAR from over colonizing the nose.

Low MSH is actually one of the risk factors for it as well, so it's a bi-directional problem.jn

How do you produce more alpha-MSG? Sun exposure. It's literally the hormone responsible for producing melanin. MB40 strain of bacillus subtilis has been shown to decolonize 70% of staph in the nose as well,

Q: Thoughts on using elemental diet for SIBO and candida?

A: I've worked with over 100 people with pretty bad SIBO and have never used it. That's not to Say it might not be necessary in extreme cases though. I've found that SIBO/SIFO needed to be managed with 1. Probiotics (tons of randomized controlled trials and meta analysis showing they do work) 2. Improving gut motility (be that nervous system interventions, addressing thyroid, using specific herbs like ginger) improving stomach acid levels, and then temporarily modifying the diet a bit and including some nonproblematic fibers in the beginning like PHGG, peels etc. That works almost 95% of the time, but you may need to tweak the order and the intensity depending on the person. The diet listed in the fungal protocol tends to work for both SIBO and SIFO (which most people usually have together). Elemental diets alone have a 2/3 SIBO relapse rate. I'm really not a big fan of super strict or low carb dieting. I would follow the fungal protocol and then reach out if you need more help

Q: Being allergic to home cats is a digestive issue?

A: Sure can! Allergies can come and go. Loss of diversity in the gut can cause the onset of new allergies, and modulating the microbiome in a positive direction can fix them. I recently did a consult with a client who's cat allergy went away after a few months on the just thrive probiotic. It's not always that simple for everyone (most will prob need fungal protocol as well), but that's probably one of the easiest things you can try first. You can find that in the bio with a discount code. Mechanistically, the gut microbiome interacts with the immune system through a ton of pathways. It will directly influences the differentiation of T-helper cells, which can skew the immune response towards either a THi (protective) or Th2 (allergic) profile. Th2-dominant response is associated with increased production of IgE antibodies, which are what cause allergic reactions. Other microbial metabolites like SFC can influence immune responses. certain bacteria produce metabolites that can enhance the function of dendritic cells and macrophages, which create a more robust immune response against pathogens while maintaining tolerance to non-harmful antigens.

Q: Do you think there's cancer cures we don't know about

A: No one is directly trying to hide cancer cures; I really don't believe that's the case. Just like coaching is an art (that requires synthesis of numerous moving parts and pieces rather than finding 'perfect' exercises or a perfect training split) practicing medicine is also an art. There are already cancer therapies, like CAR-T cell therapy and tumor infiltrating lymphocyte therapies that work extremely well. The problem is twofold:

1. Insurance often does not cover them (for example, CART cell therapy costs nearly $500,000 out of pocket), and it's often hard to get certain therapies approved.

2. Many oncologists are also hesitant to try experimental therapies due to concerns about liability and malpractice lawsuits. To truly treat cancer or any chronic disease, you often have to rely on mechanistic conjecture or be willing to try alternative approaches, such as repurposed drugs. Despite popular belief this is why integrative oncology can yield significantly better results with cancer treatment. For example, deuterium depletion is a very effective way to control cancer metastasis, has virtually zero contraindications, and does not interfere with conventional treatments like chemotherapy or radiation. The same goes for molecular hydrogen; these therapies can actually enhance tumor responses to treatment and decrease side effects. We have meta-analyses showing these benefits for hydrogen and numerous randomized controlled trials out of Europe for deuterium depletion. Same for microbiome health and immunotherapy responses. Yet, you'll be hard pressed to find any oncologist aside from an integrative oncologist-recommending these therapies or telling patients to get their gut healthy. Even top cancer centers like MD Anderson are not yet using genetically targeted fractionated chemotherapy, which involves targeting the right form of chemotherapy to the patient based on genetic

Q: I suffer with terrible IBS and rely on imodium every day, is imodium as safe as l've been told by doctors?

A: Of course not. Those drugs are horrible.

Many with IBS can get relief using things like saccromyces boulardii, tributyrin, spore based probiotics, and bovine serum immunoglobulins, BB536 and 35624 bifido strains. and If you have IBS, consider a more 'conservative' version of the fungal protocol using just those minus the enzymes and caprylic acid for a few months. gut microbiome dysbiosis is highly prevalent in IBS. I'd say in 60-70% of most people, it's the primary cause. Dr Pimentel and his group have rigorously verified empirically numerous times accross numerous publications. I'd also read the

'probiotic strain for IBS' article on the patreon and see if trying that doesn't work better than the Imodium. Neurofeedback and VNS (which I've also written articles about) are also amazing for both the psychological stress component of IBS, as well as regulating gut motility

Q: Which one is better when taking bpc-157 pill from or injection

A: Oral works perfectly fine for virtually everyone. I have a good source in the bio. You need to use it for at least 1-2 months (for most injuries, I'd really suggest two for it to be worth it though. It's not going to work overnight

Q: Is it possible to cure schizophrenia ( especially auditory hallucinations) ?

A: Yea I think so. And there's enough clinical case reports of it. There was a review done with I think over like 800 patients that found people who took high dose B-vitamins

(particularly B12 and B6 I believe) 1. in addition to their medications significantly reduced symptoms, compared to those who just took medicine. And I believe this was also replicated where B-vitamins were used alone and actually outperformed actual medication. Again that’s just one intervention. I don’t think it’s too hard to imagine would that could go if you also fixed those people's guts, did mineral balancing, heavy metal chelation ete etc. the entire package. The question is always 1. How willing are you to go to those lengths and 2.

Will those patients ever come in contact with a provider competent enough to provide that level of care. Again, this is the same story as the previous question I answered on cancer.

Its possible. It just requires a lot of work, work that most aren't willing to do or seek out directly

Q: Thoughts on having a mildly dilated aortic root at 24. Literally with no risk factors...

A: DAR, mitral valve prolapse, heart murmur...often connective tissue disorders (Ehlers danlos, Marians etc. consider heart and vascular bio-regulators to prevent worsening. usually a non issue for those that maintain good health. Also consider modified citrus pectin. Good studies showing it Attenuates atherosclerotic lesions and aortic dilation. Anything that inhibits galectin-3 (which MCP does best) will calcium from accumulating on the inner lining of the aortic root. Most of the time, valve and root issues become more problematic when there calcification and scar tissue. MCP also inhibits fibrosis. Galectin 3 will drive pathological remodeling of cardiac tissues, so keep that low is key

Q: Any supplements you think are underrated for joint connective tissue health

A: I'm a really big fan of choline stabilized orthosilicic acid. What’s great about it unlike a lot of ‘joint’ formulas is that there is a lot of really good RCT’s in humans. Ancedotally, I've also seen this be really effective for people with connective tissue disorders like EDS. Mainly for improving CT laxity and pain. It's not a fix, but it does seem to have a noticeable impact on quality of life, particularly if you stay consistent with it for at least 6-8. Then you can cycle on and oft. The RCT's themselves show symptomatic improvements in knee osteoarthritis. Significant reduction in biomarkers indicative of cartilage degradation. Pretty cool. It mainly seems to work via collagen synthesis and osteoblastic differentiation, which are needed for maintaining cartilage integrity and bone health. COSA directly stimulates the activity of osteoblasts, which are those cells responsible for bone formation. I also have like 20-30 different supplements listed in the 'injury guide' and 'bone protocol' on patreon that you can stack stuff like that with. I think its always best to use a combination approach