The ultimate eye health protocol (installment 1)

The ultimate eye health protocol covers supplements, biohacks, diet and lifestyle modifications for eye health and healing.

The first installment is a list of my top supplemental recommendations. We’ll cover some other biohacks, vitamins and dietary considerations in our second installment.

Many have used the things mentioned to improve their eyesight to a point where they no longer need contacts or glasses. The treatment of even rare genetic disorders has been experimentally demonstrated. This is documented, real world clinical results with real people. Not cell culture or animal models.

If that sounds too good to be true, you’re more than willing to run the experiments yourself…

Retinalamin (peptide bio-regulator)

Retinalamin is first on our list. It’s my primary go-to when addresing virtually any problem with the eye, regardless of etiology or genesis. This is because retinalamin works fundamentally at the most basic level — restoring cellular homeostasis and repair. Because it effectively stimulates metabolic pathways that are essential for the health and function of our photoreceptors, retinalamin has a range of potential applications for an extremely wide variety of ocular disorders. Retinalamin is a peptide bio-regulator for the eyes. In Russia, it has garnered attention for its tremendous therapeutic role in treating severe retinal disorders, particularly rod-cone dystrophy — a genetic disorder characterized by the progressive, gradual vison loss, ultimately resulting in total blindness. In fact, this is the only treatment in the world shown to be effective for RCD. It’s also been well studied for macular degeneration, nearsightedness cataracts, and other eye pathaplogies. It’s powerful stuff

How is it used?

10mg, for 10 days as a subq injection. It may be repeated every 2-3 months until pathology is reversed or at least stabilized. Courses can be repeated every 4-6 months for maintained of ocular health.

The capsule version of the peptide is called visoluten, and courses of this can be done for 20-30 days at 2-4 capsules daily and repeated in the same fashion above. Capsules are not as effective. But they can be an open for those averse to the idea of injections.

You can find it on cosmic nootropics.

DHA-plasmalogens

DHA plasmalogens are a specialized form of phospholipid that play a big role in brain and eye health. Unlike free fatty acids, DHA plasmalogens can effectively cross the blood-brain and eye-blood barrier, making them particularly beneficial for cognitive and ocular function. This unique ability allows them to integrate into neuronal membranes, enhancing membrane fluidity and flexibility, which is essential for optimal cellular function and communication.

DHA plasmalogens are predominantly found in high concentrations in the retinal cell membranes, where they are essential for the health of photoreceptors. These specialized cells are responsible for converting light into neural signals, a critical process for vision. The presence of DHA in the eye supports the structural integrity of retinal membranes and protects against damage. Having a sufficient intake of DHA plasmalogens has been shown to significantly improve field of vision and eye health. While DHA Plasmalogens are the primary form of Plasmalogens for eye health, omega-9 (prodomeGlial) can also be a good option for supporting the health and function of the eyes.

How do I take them?

1 serving daily (or every other day to save money) until desired results are attained. You can use the code DrT25 for a big 25% off (this is not my personal code and I’m not affiliated)

https://prodrome.com/en-ca/products/prodromeneuro-plasmalogen-oil-supplement

SKQ eye drops

SKQ antioxidants, particularly SkQ1, are a highly unique class of Russian synthesized compounds designed to target mitochondria and mitigate oxidative stress. Their mechanism of action is primarily based on their unique structural properties and their ability to penetrate cellular membranes effectively, unlike most antioxidants. (Starting to see a similar pattern here? Hydrogen, cell penetrating peptides/bio-regulators, SKQ etc)

SkQ1 is a lipophilic cation linked to an antioxidant moiety. Huh? That means it allows it to cross cell membranes easily. Again, this is different from other antioxidants. The positive charge of SkQ1 facilitates its accumulation in the negatively charged mitochondrial matrix, where it exerts its protective effects. This targeted delivery is crucial because mitochondria are significant sources of ROS, which — contextually — may contribute to cellular damage and aging.

Once inside the mitochondria, SKQ can selectively act as an antioxidant by neutralizing ROS when and where needed.

Research indicates that SkQ1 may have therapeutic potential in treating age-related diseases, neurodegenerative disorders, and conditions characterized by mitochondrial dysfunction. Its ability to target mitochondria and reduce oxidative stress positions it as a good candidate for various medical applications, including most notably… eye health. It has been studied for its effects on conditions like dry eye syndrome and corneal damage.

Research has demonstrated that SKQ significantly enhances corneal healing following damage from UV light exposure and mechanical injuries. In experimental models, pre-treatment with SKQ before UV exposure resulted in minimal corneal damage compared to control groups, indicating it might have protective effects against oxidative stress induced by UV radiation and likely other environmental and disease caused insults. when applied after corneal injuries, SkQ accelerated the healing process, allowing for faster recovery of the corneal epithelium.

How do I use it

2-3 drops in eyes until results are seen

https://us.amazon.com/Generic-Visomitin-Supports-Wellness-Irritation/dp/B0DBHTCB9M

Carbon 60

Carbon 60/C60 (or sometimes called) fullerene)has gained a lot of attention for its unique health benefits. particularly in the context of eye health.

Fullerol has been shown to preferentially accumulate in muller cells, a type of glial cell in the retina. These cells play a role in supporting retinal neurons, maintaining the blood-retinal barrier, and responding to injury. The ability of fullerol to concentrate in these cells makes me believe that it can directly influence their function and fate (we have seen this demonstrated in some small papers) which is crucial for retinal recovery from damage.

fullerol modulates several critical gene pathways involved in retinal protectio. It’s been shown that fullerol influences the fate of Muller glia by promoting their de-differentiation and inhibiting gliosis (aka the process by which glial cells become over reactive in response to injury). This modulation is significant because gliosis can lead to detrimental effects on retinal function. By modulating the TGF pathway, which is associated with gliosis, and selectively enhancing pathways like Nrf2 and Wnt10a, fullerol helps maintain the health and functionality of muller cells, greatly augmenting their role in retinal repair and regeneration. We effectively shift from pro-inflammatory to anti-inflammatory (& repair) MC biology

While we don’t have a lot of definitive research on carbon 60 for eye health, we do have a lot of anecdotes on macular degeneration and improvements in eyesight and field of vision. Juxtaposed against the promising mechanistic research available, and I think you can make a good case for at least trying carbon 60.

How do I use it?

1 serving daily for a few months until results are achieved. Dosing is subjective and there isn’t good research to say exactly what does and doesn’t work. Experiment and see what works for you.

https://wizardsciences.com/products/evolve-rx

DMSO eye drops

DMSO gained a lot of attention many years ago for its potential therapeutic applications, particularly in treating eye diseases such as macular degeneration and retinitis pigmentosa (one of the only other effective treatments for RP aside from bio-regulators. This interest largely stems from the pioneering work of Dr. Stanley Jacob, Chief of Transplant Surgery at the University of Oregon, who initially explored DMSO's capabilities in organ preservation and later its effects on various medical conditions.

Dr. Jacob's exploration of DMSO began in the 1960s when he discovered its unique properties as a solvent that could penetrate biological membranes. This led to its application in medical treatments, particularly for musculoskeletal disorders which I’ve discussed at length. Notably, several patients receiving DMSO for these conditions reported unexpected improvements in their vision. Those clinical ancedotes prompted Dr. Jacob to collaborate with Dr. Robert O. Hill, an ophthalmologist at the University of Oregon Medical,

Dr. Hill's research confirmed that DMSO could be effective in treating retinitis pigmentosa and macular degeneration. His studies indicated that a 50% DMSO solution applied as eye drops resulted in significant improvements in visual acuity and overall eye health for some patients. In a notable presentation at the New York Academy of Sciences symposium in 1971, Dr. Hill shared findings that highlighted the potential of DMSO in ophthalmology, particularly for conditions previously deemed incurable.

Despite its promising applications, DMSO's journey through the medical landscape has been fraught with regulatory challenges. Initially approved for interstitial cystitis in 1978, DMSO's use for other conditions has been subject to scrutiny. However, legal precedents have established that physicians can prescribe DMSO for off-label uses based on their clinical judgment, allowing for broader applications in treating various ailments, including eye diseases

How is it used?

A solution of 50% DMSO is used in the eye. Personally, I prefer weaker concentractions (around 40% liquid DMSO) for this. 1 drop in each eye until symptoms improved. Its

https://dmso.store/product-tag/eye-drops/

BPC-157 eye drops (cornea damage)

BPC-157, a synthetic peptide derived from a naturally occurring protein in gastric juice. Its well known for its regenerative properties across multiple tissues, including muscles, tendons, and nerves. Its mechanisms of action are believed to include promoting angiogenesis (aka the formation of new blood vessels), modulating inflammation, and supporting tissue regeneration at the cellular level. Although much of the research has been conducted in animal models, preliminary findings indicate that BPC-157 may also benefit ocular tissues, particularly the retina and cornea, which are susceptible to injury and degeneration

The retina is a critical component of the eye. As mentioned above, its responsible for converting light into signals for the brain. Damage to the retina leads to severe vision loss. Early animal studies have shown that BPC-157 can reduce retinal damage and improve structural integrity following injuries. Laboratory experiments suggest that it could enhance the survival and growth of retinal cells under stress, such as low oxygen conditions.

The cornea, the eye's outermost layer, is vulnerable to abrasions, infections, and degenerative conditions. Current treatments often involve extremely ineffective antibiotic and anti-inflammatory medications. BPC has anti-inflammatory properties that can directly reduce scarring (aka fibrosis) and promote smoother healing of corneal injuries. If formulated into eye drops or gels, BPC (like other topical applications) can be a powerful, non-invasive adjunct therapy,

How is it used?

For corneal injuries, BPC can be applied topically in eye drops and injected (not into the eye but the stomach or elsewhere for the systemic healing effects). For injections, the dosage is 500-1000mcg. CanLabs brand or capsules (infiniwell brand) is recommended. For eye drops, 2-3 drops in the effected eye. Use a dropper bottle with the BPC spray bellow (science.bio brand). It’s possible that topical BPC may also improve general visual function, although this seems to be more applicable for actual eye injuries or existing structural damage or pathology

https://science.bio/product/bpc-157-spray-50mg/

Can these all be taken together?

For those with serious retinal disorders, it may be advisable to use a combination approach. Starting with things at the top of the list, and working your way down. I tried to put these in order of highest priority. I don’t see any real issue using all of these at the same time. It’s just a matter of cost, severity and context.

Nutrients, vitamins and other antioxidants

C3G (for ‘night vision’, glaucoma, prevents Cataract formation, possibly sports vision and nearsightedness)

Cyanidin-3-glucoside a powerful antioxidant found in fruits and vegetables, particularly in black currants and other colored legumes. Its benefits for eye health are supported by a growing body of clinical research.

C3G specifically helps to protect retinal cells from damage. Some research also indicates that C3G can enhance visual performance, particularly in low-light conditions (it improves night vision). It aids in the regeneration of rhodopsin, a light-sensitive protein in the retina that is essential for night vision. Faster regeneration of rhodopsin allows for quicker adaptation to changes in light, which is beneficial for activities requiring acute vision in dim environments.

C3G also reduces retinal inflammation and damage. In studies involving animal models, C3G has protective effects against retinal cell apoptosis (cell death) due to high glucose levels, which is particularly relevant for individuals with diabetes. This protective role extends to preventing vascular leakage and neovascularization associated with diabetic retinopathy, thereby maintaining retinal integrity

Another interesting compnent of C3G is that it also improves blood flow to the eyes. Enhanced circulation can help deliver essential nutrients to the retina and remove metabolic waste, supporting visual acuity and overall eye health. This is particularly important for individuals suffering from conditions like glaucoma, where ocular circulation is often compromised.

A clinical study involving participants with nearsightedness demonstrated that supplementation with C3G rich black soybean hull extract significantly improved symptoms such as eye dryness, blurred vision, and eye fatigue. The study reported a big improvement in visual acuity after eight weeks of supplementation, indicating that C3G can have a tangible impact on vision quality. Yay! Human evidence

250-500mg daily is the dose. It can be a little stimulating (also great for body comp and gut health) so I’d take it in the morning. Nootropics depot makes a good one

Vitamin A

One of the most well-known benefits of vitamin A is its significant role in eye health. It is essential for the formation of rhodopsin, a pigment we mentioned above that’s in the retina that allows us to see in low-light conditions. A deficiency in vitamin A can lead to night blindness and other vision problems. adequate intake of vitamin A has been linked to a reduced risk of age-related macular degeneration, which is a leading cause of vision loss in older adults

The best way to get vitamin A (in the bioavaliable form retinol) is full fat dairy, egg yolks, and organ meats. No need to supplement this one.

Taurine

Taurine is a sulphur containing amino acid that is essential for the health of retinal cells, particularly photoreceptors and retinal ganglion cells. Research indicates that taurine provides neuroprotection against the degeneration of these cells. A deficiency in taurine can lead to significant visual dysfunction, as observed in both human and animal studies. Supplementation with taurine has been shown to reverse some of the visual impairments associated.

Taurine also plays a role in alleviating visual fatigue, a common issue for those who spend long hours in front of screens or in bright environments. Prolonged exposure to these conditions can lead to the accumulation of metabolic waste in the eyes, resulting in strain. Taurine helps clear that waste and supports the movement of essential nutrients within the eye,

Taurine is also important for night vision. While vitamin A is well-known for its role in low-light vision, taurine is anther nutrient that complements this function by protecting photoreceptors from damage.

Taurine is also involved in the regulation of calcium ions in retinal cells, which is crucial for maintaining cellular function and signaling. Proper calcium homeostasis is essential for the health of photoreceptors and RGCs, as it influences neurotransmitter release and cell survival. Disruptions in calcium levels lead to cell death and vision loss, making taurine's regulatory role big here

I like to supplement with 3g of taurine 4-5x a week, usually during training. Because it’s an osmoregulator, it’s great to throw into your water along with some salt for hydration. Bulk supplements is the brand I use

Red light therapy (dry eye syndrome, general retinal function, macular degeneration, glaucoma

Red light therapy operates through a process known as photobiomodulation, which involves the absorption of red and near-infrared light by mitochondria, the energy-producing organelles in our cells. When these cells absorb light, it enhances their ability to produce ATP, the primary energy currency of the cell. Increased ATP production leads to improved cellular function, repair, and obviously therefore regeneration.

RLT can improve blood circulation to the eyes, which is important for delivering essential nutrients and oxygen to retinal tissues. Enhanced blood flow can also help remove metabolic waste products, further supporting retinal health and function. This works in great synergy with taurine and CG3 for this reason.

One of the primary applications of red light therapy is to enhance basic retinal function. By increasing mitochondrial energy production, RLT will improve the efficiency of retinal cells. Clinical HUMAN studies have shown that patients receiving RLT exhibit significant improvements in vision and retinal function. This is no small or minor benefit either. These improvements are massive

RLT is also great for dry eye syndrome is a common condition characterized by insufficient tear production and poor tear quality. Red light therapy has been shown to stimulate tear production

RLT may also be therapeutic for Glaucoma, a group of eye diseases that damage the optic nerve and lead to vision loss. RLT enhances the viability of retinal ganglion cells.

Age-related macular degeneration is another leading cause of vision loss in older adults, and a conditin where RLT shows big benefits. Some studies suggest that red light therapy may help slow or even reverse the progression of AMD by enhancing mitochondrial function and reducing inflammation in retinal cells.

You can check out the ‘red light therapy buyers guide’ article on where to find a good red light. Morning and evening sun (don’t stare directly at the sun obviously) is also another great way to get casual exposure to red light in the eyes. Morning and evening sun is almost entirely red light. 10-15min using an RLT panel and shining in the direction of your eyes (just look down and off to the side instead of straight at the device) is great for the eyes.

(To be continued)