Solutions for H pylori

Similar to other infections like Candida and SIBO, H pylori is highly prevelant. It’s estimated that around 50% of the adult US population has an opportunistic overgrowth of H pylori in the gut.

H pylori is a type of bacteria that primarily infects the stomach. It is known to be a major cause of peptic ulcers and is associated with several gastrointestinal conditions, including gastritis, leaky gut, endotoximia and gastric cancers as well

increased intestinal permeability (where the lining of the small intestine becomes damaged) allowes bacteria, toxins, and undigested food particles to ‘leak’ into the bloodstream. H pylori can contribute to leaky gut through several mechanisms:

1. pylori infection causes chronic inflammation in the stomach lining, which can extend to the intestines, disrupting the tight junctions between epithelial cells.

2.The body's immune response to h pylori is often aggressive and can produce cytokines and other inflammatory mediators that damage the intestinal lining. h pylori and the immune mediated, systemic chronic inflammation it causes is often worse than other opportunittic infections like Candida and SIBO. Getting it under control is important

3. H pylori can produce enzymes and toxins (like VacA) that directly damage epithelial cells and degrade the mucosal barrier. Increased intestinal barrier permeability (leaky gut) allows endotoxins from the gut microbiota to enter the bloodstream, promoting additional systemic inflammation.

Contribution to Cancer:

H pylori is classified as a group 1 carcinogen by the International Agency for Research on Cancer. It can contribute to cancer, particularly gastric cancer because

persistent infection leads to chronic gastritis, which can progress to atrophic gastritis, intestinal metaplasia, dysplasia, and eventually gastric cancer.

Many bacteria can also produce reactive oxygen species and other mutagenic chemicals that can cause DNA damage in gastric epithelial cells. H pylori can also activate several cellular pathways that promote cell proliferation and survival, such as the NFkB and Wnt/b-catenin pathways.

Solutions for H pylori

1.Limosilactobacillus: A sign single strain probiotic solution?

Limosilactobacillus reuteri DSM 17648 is a specific strain of probiotic bacteria that has been studied for its effects ONLYA on H pylori. You can think of this strain a specific, targeted bacteria for managing H pylori without impacting the rest of your microbiome

Interestingly, even when this probiotic strain is non-viable (dead), it still exerts beneficial effects against H. pylori. Here’s how it works:

L reuteri has surface proteins and other molecules that can bind directly to H pylori bacteria. This binding can inhibit the ability of it to adhere to the gastric mucosa, which is a critical step in in the colonization and pathogenicitc of pylori. By binding to pylori, the dead cells of this bacteria can reduce the overall pathogen load in the stomach where they can be excreted in stool

Even though the cells are not alive, their physical presence can still play a role in competitive exclusion. By occupying space and resources, they can limit the ability of H pylori to thrive in the gastric environment.

The dead cells can still release bioactive compounds such as cell wall fragments, peptidoglycans, and other metabolites. These compounds can exert antibacterial effects against H. pylori, inhibiting its growth and activity.

https://amzn.to/3W8yFih

Dosing: 1 serving for 1 month

2.HU58 high dose single strain spore

Bacillus subtilis HU58 (a strain in the jusr thrive) is a probiotic known for its stability and resilience, particularly as a spore-forming bacterium that can survive harsh conditions and reach the gut intact.

While specific research on HU58 and its direct activity against pylori are limited, there are several general mechanisms by which this strains can contribute to controlling opportunistic infections and microorganisms in the gut

Bacillus subtilis strains are known to produce a variety of antimicrobial substances, such as bacteriocins, lipopeptides, and enzymes, which can inhibit the growth of pathogenic bacteria, These compounds can disrupt bacterial cell walls or interfere with their metabolic processes in addition to amelorating the biofilms they hide in

Spores like HU58 can colonize the gut and compete with pathogenic bacteria like H pylori for nutrients and adhesion sites. This competitive exclusion can reduce the ability of H pylori to establish and maintain an infection in the gastric mucosa.

While I typically recommend that most people use a good ‘base’ probiotic like the Just Thrive for general gut health, adding in a higher dose of single strain HU58 can be really effective for those dealing with dysbiosis and opportunistic infections like H pylori.

https://amzn.to/3XRB8PI

Theoretical/research Dosing: 1 serving daily for 1-2 months

3. Bacteriophages

bacteriophages, which are viruses that infect and kill specific bacteria (but CANNOT infect human cells) have shown potential in treating h pylori. Bacteriophages are highly specific to their bacterial hosts. Phages that target H pylori can attach to the bacterial cell surface and inject their genetic material into the bacterium. Once inside, the phage hijacks the bacterial cellular machinery to replicate its own genetic material and produce new phage particles. The replication process continues until the bacterial cell is filled with new phage particles. The bacterium then bursts (lyses), releasing the new phages to infect adjacent H pylori cells.

Phages target only specific bacteria, reducing the risk of harming beneficial microbiota in the human gut. Because Phages can evolve alongside bacteria, they potentially reducing the issue of resistance that is common with antibiotics. Phages are safe and do not produce side effects aside from potential bacterial die off

https://amzn.to/3zvcfPw

Theoretical/research dosing: 2 capsules daily for 1 month

4. Bovine serum immunoglobulins

Bovine serum immunoglobulins have been explored as an alternative or adjunctive treatment for h pylori. immunoglobulins are derived from the serum of cows and contain antibodies that can neutralize pathogens,

Some small trials have shown that bovine serum immunoglobulins can bind to H pylori and neutralize its virulence factors, which may reduce infection and associated inflammation. Some research also indicates that BSI can help reduce the bacterial load of pylori in the stomach, potentially improving symptoms of bacterial die off (‘detox’ symptoms) and aiding in the eradication of the bacteria itself as well. BSI are beneficial for managing and binding endotoxin from leaky gut, as well as other toxic compounds release from bad bacteria.

Bovine serum immunoglobulins might have synergistic effects when used in conjunction with antibiotics, potentially enhancing the efficacy of conventional treatments and reducing the required dosage of antibiotics

https://amzn.to/3WkaWfv

Theoretical/research dosing: 1-2 servings daily before meals for 2 months

Zinc carnosine (for ulcers and leaky gut)

Zinc carnosine (specifically the carnosine form) is beneficial for gastrointestinal health through several mechanisms. It stabilizes the gut lining, reduces inflammation, and promotes tissue repair, aiding in the healing of gastric and duodenal and peptic ulcers. Zinc carnosine has antibacterial properties, enhances the effectiveness of antibiotics against H pylori, and strengthens the mucosal barrier, protecting the stomach lining. It helps tighten the junctions between intestinal cells, reduces inflammation, and supports the repair of the gut lining, improving intestinal permeability.

https://www.mitolife.co/products/zinc-carnosine-complex

Theoretical Dosing: 1 capsule (16mg) daily with meals

Code: GRANFOWLER15