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Induced Mots - c Production (Longevity series)

Added 2021-02-11 15:38:15 +0000 UTC

Healthy aging can be promoted by enhanced metabolic fitness and physical capacity. Mitochondria are chief metabolic organelles with strong implications in aging.

The progressive loss of metabolic homeostasis is a hallmark of aging, which impedes parenchymal function and ultimately diminishes physical capacity.

Mitochondria not only produce the bulk of cellular energy, but also coordinate adaptive cellular homeostasis.

MOTS-c (mitochondrial ORF of the 12S rRNA type-c) is an MDP that promotes metabolic homeostasis, in part, via AMPK, and by directly regulating adaptive nuclear gene expression following nuclear translocation. MOTS-c expression is age-dependent and detected in multiple tissues, including skeletal muscle, and in circulation, thus it has been dubbed a “mitochondrial hormone or “mitokine.

It had been observed in aging mice that systemic MOTS-c treatment reversed diet-induced obesity and diet- and age-dependent insulin resistance.

This is designed to work to induce the productions of mtDNA-encoded MOTS-c. (its naturally induced with exercise) In experimental subjects it was observed that MOTS-c treatment significantly improves physical performance regulates skeletal muscle metabolism and gene expression, and finally enhances adaptation to metabolic stress in C2C12 cells in an HSF1-dependent manner.

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(research from https://www.nature.com/)