POD 80: Dr. Jackie von Salm & Jeanine Yacoub on sponges, mushrooms, and new tryptamine psychedelics
Added 2023-07-13 03:07:24 +0000 UTCRecorded at the recent MAPS conference, this is a conversation with two chemists from Psilera Dr. Jackie von Salm and Jeanine Yacoub, M.S. We discuss tricyclic tryptamines found in nature, sponge natural products, and the future of psychedelic medicinal chemistry.
https://pubs.acs.org/doi/pdf/10.1021/acs.jnatprod.2c00716
Prophetic Compounds in Patents
Comments
Always cool to see women in this space. I dont understand why this is such a male dominated subject both academically and recreationally but it certainly is. Diversity is important to give us different lenses to explore these things, love it!
Rain Bear
2023-09-21 00:21:50 +0000 UTCGahhh as someone who wants to make it their life goal to save the coral and invest in coral farming it's super rad that yall touched on how marine life does potentially have medicinal properties that could be helpful in pharmacology. I'm a big believer that nature provides many medicines that could be beneficial to us and to hear about it unexpectedly was super rad. I think it is crucial to help the sea and coral because it so untouched with a large variety of mysteries that have yet to be uncovered and now its dying so I'm dedicating my life to aiding it in any way I can and this interview just gave me sooo much inspiration. It's funny how the universe just throws sychronisties your way that further support your life goals. This and a medical study I was in for some Doctors in the SF area that created some probiotics that healed my IBS, extremely grateful one of my bestfriends was working with them on this and I got to test the probiotics because it truly was life changing and some of the ingredients were also from marine lifeπ thankyou so much :3
Lightfaeee
2023-09-16 12:12:08 +0000 UTCGood interview, I wish I had a chance to talk to them in Denver! When will we see a Jitka interview?
Michael Cunningham
2023-08-23 18:48:51 +0000 UTCUsing salt formation as a purification technique really depends on what one is trying to remove in the purification. If, for example, you were trying to remove oils from an alkaloid then salting and washing with a non-polar solvent can be very effective but if you were trying to do something like isolate NMT from DMT salting and washing would not be an effective strategy. In the last graph you describe the traditional method for DMT extraction i.e., an "acid-base extraction" instead of STB, that works very well but is unnecessary with MHRB because the fat content of the bark is low.
Hamilton Morris
2023-07-25 15:11:23 +0000 UTCDuring the tips and tricks portion at the end, she says that DMT can be salted out of directly from crude material to get DMT fumarate without a column. Then to get it back, use sodium hydroxide and DCM for pure DMT. Does that strategy apply to extractions or synthesis? For the average kitchen extractor without knowledge of running a column in the first place, how can this tip be applied to a home extraction of root bark for pure DMT? Can one boil the bark with water + fumaric acid for the initial solid to liquid extraction, then freebase with NaOH, then pull with DCM? How would DCM result in a more pure extract than say Heptane?
brandonslemaster
2023-07-22 22:39:35 +0000 UTCOh man, alpha methyl tryptamine is such a cool drug, it was interesting to hear it mentioned at the end. Whether looking at it chemically or pharmacologically, it is very interesting because it is essentially βwhat if amphetamine was a tryptamine instead of a phenethylamineβ and it ends up giving effects that are essentially exactly how you would imagine that feeling. It has the weird trippiness of tryptamines but itβs also not so trippy that you canβt handle yourself in public. Mixed in with that, it feels like a stimulant/empathogen mix. Like not just a stimmier empathogen feel like with something like 4-mmc, but it had the sharpness and clarity of amphetamine mixed in with some of the body euphoria and emotional openness of an empathogen. Also the history of its use as an antidepressant in the soviet union is interesting since it is a very novel approach, pharmacologically speaking, of attempting to treat depression. I was fortunate to have multiple doses that I could share with some friend over a few different trips. It was completely off market for years, but my dealer turned friend and later roommate collected RCs for years and had picked it up during a limited production of it by a well respected dark net lsd distributor at the time. We actually bonded over rcs since i was the first and only person to ever ask if they had 3-meo-pcp or mxe after being told they had a safe with βdrugs you never even heard ofβ. They did have these drugs (again, this was after mxe was scheduled and disappeared from the market besides for scam listings or at exorbitant prices) and the rest is history. aMT is such an interesting and wholly unique drug, although then come up could really suck. Itβs definitely one of those drugs I am very happy i got the opportunity to try when I was actively using and seeking out various RCs.
Addicted to Chloroform
2023-07-22 05:37:36 +0000 UTCLove the chemistry content! Thanks for sharing Hamilton!!
Bret
2023-07-13 17:20:16 +0000 UTCLove this. I'm still very much a chemistry noob, but I am here for it. It's strange to me when others don't find it fascinating. I wanted to go to the Denver conference this year, but that didn't happen. Maybe next year! Any chance you'll make it to the Horizons conference in Portland, OR this year?
Laura
2023-07-13 17:09:23 +0000 UTC
