Ryan’s heart failure protocol

For those who are not familiar with the story, my friend Ryan Brown had two heart attacks last year following severe mold illness, COVID-19, and suspected complications from bodybuilding and prescription medications. Ryan was diagnosed with severe left ventricular hypertrophy and stage 3 heart failure. While we don’t know exactly what predominantly contributed to Ryan’s condition, we do know precisely what he did that helped him reverse it. That’s what we will discuss today.

This is a story that I think pertains to everyone. Regardless of wether you have a heart condition or not. Ryan’s story exemplifies powerful, axiomatic truths about the bodies extrodinary ability to self-repair and heal when given the right inputs. I think this is something everyone can get behind. Plenty of science has also been included here for those that curious

I want to provide a little context here:

1. Stage 3 heart failure is considered irreversible, at least from the standpoint of modern conventional care. It’s both progressive and ultimately fatal.

2. Ryan completely reversed his stage 3 heart failure. He didn’t take it from stage 3 down to stage 2 or 1; he COMPLETELY reversed it. Can I say ‘cured’ it? I know that’s a controversial term, but it’s the truth. His cardiologist—who was just as shocked as he was—confirmed it.

Ryan reversed his heart failure. Completely. Full stop. He has the imaging to prove it. What follows is exactly (compound for compound, dosing, etc.) what Ryan did. That’s it. It’s information. I’m not claiming this will work for everyone or that anyone should attempt treatment unless they are under the guidance of an informed physician.

The information provided in this article is not medical advice. It consists mostly of experimental treatments that, while supported by some literature, are not ‘proven’ beyond a shadow of a doubt. They include biohacks, peptides, and supplements.

While virtually all of these treatments (especially the peptides) appear to be safe based on experimental and clinical evidence, they are not approved treatments in the United States. It’s always possible that different individuals could respond in various ways (particularly to certain dietary supplements) if they’re on medication.

Most of the research on peptides (particularly bio-regulator peptides) and their ability to regenerate organs and attenuate damage is difficult to find because much of it is published in Russian journals.

A lot of this research involves humans, while some is conducted in culture and animal models. We draw from both. Different peptides and therapies have varying levels of clinical and experimental evidence. Some substances, like D-ribose, are well established for treating heart failure, while others haven’t yet made it into clinical trials for humans. Some are well established, but I won’t claim that all of them are proven beyond a shadow of a doubt.

What we do know is that most of these therapies have very few downsides. Some of the less well-studied therapies have seen extensive use in humans and biohackers, with few documented downsides. For example, many of the bio-regulator peptides listed below have been used in Russia for over 40 years by millions of individuals, and no serious adverse effects have been reported.

That being said, I’ll repeat that none of this is medical advice. These are not approved therapies in the United States, and most of the injectable peptides listed below are ‘not for human consumption.’ They are primarily sold by research chemical companies. While I trust sources like CanLabs (the founder of which has an extensive background in peptide research and development, as well as a proven track record of producing pure, quality products), these compounds are considered ‘experimental’ and ‘unregulated.’

By signing up for the Patreon, you already acknowledged that the information provided here is for informational and educational purposes only. You will use it for no other purpose.

(If you’d like more general information on the bio-regulator peptides that make up a significant part of Ryan’s protocol, you can check out the documentary below.)

https://youtu.be/c_GLtI01ykU?si=XzCFdnJbw7-FOjVS

With those caveats, let’s get into the meat and potatoes of Ryan’s protocol.

Bio-regulator Peptide Protocol

These peptide bio-regulators were selected primarily for their impact on the heart. The first three listed are the most important, with Cardiogen and Chelohart being the primary bio-regulator peptides for the heart. Chelohart is the capsule version. The bio-regulators listed below are all injectables.

1. Cardiogen— Prevents scarring and fibrosis while activating ‘repair’ programs in the heart. It boosts cardiomyocyte proliferation (heart cells) and cardiac progenitor cells, which are multipotent stem cells that can differentiate into cardiomyocytes, endothelial cells, and vascular smooth muscle cells.

2. Livagen— Modulates changes in gene expression related to lymphocyte (immune cell) activity in the heart, reducing inflammation and fibrosis (scarring).

3. Cartalax — Selectively reduces apoptosis (cell death) in damaged tissues, attenuates fibrosis, and promotes remodeling in the extracellular matrix. Cartalax acts as a homeostatic agent, balancing the function and health of fibroblasts, making it widely useful in virtually all major organs and tissues. Cartalax can also help mobilize stem cells to the site of injury.

4. Vilon — A thymic peptide with powerful benefits for boosting the immune system. It works by activating numerous genes in the heart necessary for proper cardiovascular function and health. Vilon also reduces micro-vessel permeability and regulates the function of glycoproteins like antithrombin to prevent clotting.

5. Vesugen — The primary bio-regulator peptide for the vasculature. It regulates hemostatic function, vascular tone, inflammation, and platelet activity. Vesugen is highly anti-inflammatory and boosts the proliferation and differentiation of stem cells to sites of injury. It attentuates hypoxia, a common issue following heart attacks and strokes

6. Epitalon — One of the first bio-regulator peptides discovered in the 1980s, it has amassed a large body of experimental and clinical evidence backing its use as a geoprotector. It’s well known for its role in regulating the pineal gland, sleep-wake cycles, and melatonin production. What’s often not mentioned is Epitalon’s role in the heart; similar to Cartalax, it can prevent excessive fibrosis (scarring in the heart) and upregulates hundreds of genes critical for cardiac function, repair, and homeostasis.

7. Thymalin — Another one of the ‘primary’ bio-regulator peptides. Thymalin, Epitalon, and Cortexin are considered the ‘big three.’ Thymalin (along with Cortexin) has been approved as a drug in Russia. It is a powerful regulator of immune homeostasis, suppressing inflammation and balancing the production of pro-inflammatory cytokines in various organs and tissues, including the heart. Thymalin is highly cardioprotective and has been studied for its ability to regulate smooth muscle contraction, heart rhythm, and prevent arrhythmias/palpitations.

How Were They Used?

Because Ryan’s condition was particularly serious following the two heart attacks he sustained, we dosed the majority of these bio-regulators at particularly high doses and for a longer period than what’s often recommended for bio-regulator peptides in generally healthy populations. Because bio-regulator peptides have virtually no side effects, they can be dosed high and for prolonged periods.

We administered all of the above peptides at 5 mg for 40 days straight. Livagen and Cardiogen were continued for another two months at a low maintenance dose of 1 mg for good measure, and Chelohart (the capsule version) was continued for four months at a low maintenance dose of 2 capsules daily. The only exception here was Thymalin, which was dosed for only 20 days at 10 mg. All peptides were sourced from CanLabs, except for Thymalin, which was sourced from Cosmic Nootropics, and Chelohart from Natures Marvels.

This was not particularly cheap—somewhere around $3,500 for just this 40-day bio-regulator cycle. However, I do believe it played a massive role in Ryan’s recovery. I genuinely think it was the predominant factor. I had a good majority of these peptides sitting in my freezer, which I immediately delivered to Ryan. Improvements in symptoms like anxiety and shortness of breath were apparent within days, long before the other peptides had a chance to arrive.

For less serious conditions, lower doses of 1-2 mg for short cycles of 10-20 days would likely work and provide substantial benefits over the long haul if repeated (generally 2-3 times a year). Ryan now follows a yearly maintenance health protocol similar to this one with the above peptides used in lower, less frequent doses.

Other peptides/injectable’s

Thymosin-beta-4 —. TB4 was another extremely crucial peptide in Ryan’s stack. TB4, while not considered a bio-regulator peptide, has many ‘bio-regulator like’ effects comparable to Cardiogen. TB4 plays a crucial role in heart repair and regeneration by activating embryonic programs. It promotes the migration and proliferation of cardiomyocytes and cardiac progenitor cells, which are huge for healing damaged tissue. It also enhances the mobilization of stem cells to injury sites, allowing them to differentiate into various necessary cell types, including cardiomyocytes. Additionally, it helps reduce apoptosis, or programmed cell death, in damaged areas, ensuring that more cells can contribute to recovery. TB4 influences the extracellular matrix, promoting the remodeling needed to restore the heart's structural integrity. It activates genes associated with embryonic development and repair, essentially kicking off pathways that are typically only active during heart development in embryos. TB4 is often described as a molecule that is ‘capable of reminding the adult mammalian heart of its embryonic program’. these combined actions allow TH4 to mimic aspects of embryonic heart development, making it a powerful player in promoting repair and regeneration in adult heart tissue, which is often poor .

Ryan’s dosing — 10mg daily for 7 days, then 2mg daily for a month followed by 2mg dosed 3x a week (Canlabs source)

SS-31

SS-31 (sometimes called elamipretide) is a peptide that is particularly beneficial in the context of cardiac dysfunction and injury. It primarily targets and protects mitochondria. By stabilizing mitochondrial membranes and, it improves cellular energy production, which is necessary for maintaining the function of cardiomyocytes (heart muscle cells). Think of Cardiogen and TB4 as ‘regenerators’ of our heart cells, and SS-31 as jet fuel for those cells. SS-3 improves cardiac contractility and overall function, making it beneficial for conditions such as heart failure and cardiac complications in general. It may also mitigate inflammation in cardiac tissue, promoting a healthier micro-environment for healing and recovery after injury. In models of myocardial infarctio (basically a heart attack) it improves recovery outcomes, potentially enhancing tissue repair and reducing scar formation.

Ryan’s dosing — 4mg daily for 30 days (Canlabs source). This was one of the more expensive peptides, so it was used in a relatively short ‘booster’ cycle.

Injectable L-carnatine

Oral L-Carnatine is a popular supplement for heart health. Injectable carnitine is even better. in heart failure patients, it has several documented benefits, the majority of which are primarily mediated via its role in energy metabolism. Carnitine facilitates the transport of fatty acids into the mitochondria, where they are oxidized to produce energy, which is crucial for heart muscle function. This can enhance the efficiency of energy production in cardiac cells, potentially improving overall heart function and exercise tolerance. carnitine has antioxidant properties that help reduce oxidative stress in the heart, protecting cardiac cells from damage. It may also improve mitochondrial function and promote the utilization of fats as an energy source, which can be beneficial in heart failure where the heart's energy metabolism is often impaired., carnitine has been shown to have anti-inflammatory effects, which can help reduce inflammation within cardiac tissues.

Ryan’s dosing — 500mg daily.l for 3 months. Nectar, better through biology brand.

Biohacks

Molecular hydrogen

New, exiting research is constantly coming out on molecular hydrogen gas. it’s easily one of my favorite ‘biohacks’. Molecular hydrogen has gained a lot of attention recently for its potential cardioprotective effects, particularly following heart attacks. The available literature suggests several mechanisms through which hydrogen inhalation can benefit cardiac health.

inhaling molecular hydrogen can significantly reduce the area of damaged heart muscle after a heart attack. H2 has selective antioxidant properties, which help mitigate oxidative after ischemia. Hydrogen can limit the total extent of myocardial injury, preserving more heart tissue and improving overall recovery outcomes.In addition to reducing damage, hydrogen also improves left ventricular function. Several studies have reported enhancements in cardiac contractility and efficiency following hydrogen inhilation. Enhanced left ventricular function is particularly key for patients recovering from a heart attack since it directly impacts overall heart health and significantly reduces the risk of developing heart failure.

Ryan’s hydrogen protocol — 3-4 hours of hydrogen inhilation daily with hydrogen4health generator

(To be continued)

Supplements

Specialized pro-resolving mediators

SPM’s are a crucial class of molecules for promoting the resolution of inflammation and facilitating tissue repair in damaged tissues, especially the heart following events like myocardial infarction. After a heart attack, the body initiates an inflammatory response that, while necessary for healing, can become maladaptive if it doesn't resolve properly. This can lead to poor remodeling and excessive fibrosis (aka scar tissue) SPMs biosynthesis (consistent king of resolvins, lipoxins, and maresins) essentially help to turn off this inflammatory response while also promote authentic healing.

These mediators are biosynthesized by leukocytes in the spleen and are activated in response to injury. This is the acute phase after a myocardial infarction, where activated monocytes and macrophages drive the production of SPMs. The benefits of SPMs for the heart are significant. They not only help in resolving inflammation as mentioned but also enhance tissue repair and regeneration unlike most anti inflammatory compounds. SPMs can promote the survival and proliferation of cardiomyocytes, improve cardiac function, and reduce the risk of adverse remodeling that can lead to heart failure.

Ryan’s dosing — 6 capsules (metagenics SPM’s) daily for 1 month. Then 3 months of maintiance dosing at 2 capsules

D-ribose

Clinically, D-ribose has been used in various studies and treatments for heart failure, often in conjunction with other therapies. Research has indicated improvements in exercise capacity and quality of life for patients with chronic heart failure. Some healthcare providers may recommend D-ribose supplementation as part of a comprehensive treatment plan, although D-ribose by itself will not ‘reverse’ heart failure. It was mainly an adjucnt to help better facilitate other aspects of the protocol.

Ribose has benefits heart failure primarily through its role in enhancing energy metabolism. In heart failure, the heart's ability to produce ATP is compromised. Ribose is a sugar that helps in the synthesis of ATP. supplementing with it improves cardiac AtP, improving energy availability for the over worked heart.

Ryan’s dosing — high doses of 30mg for 1 month, then 10mg for 6 months

Plasmalogens

Plasmalogens are a class of phospholipids that play a big role in cellular function and have several benefits for heart health. They make up a large majority of our cell membranes, particularly in the heart and brain. They are crucial for membrane integrity and cellular signaling.

Plasmalogens can also act as sacrificial antioxidants by being released from cell membranes to combat oxidative stress and inflammation. When oxidative stress occurs, plasmalogens in the cell membrane can be oxidized themselves, effectively sacrificing their structure to neutralize harmful ROS. In this process, replacing lost Plasmalogens is absolutely crucial to.maintain cellular homeostasis.

Ryan’s dosing — 1 dose of ProdromeNeuro and 3 doses of Prodrome Glial daily for 3 months

(To be continued…)