WIP video about Alphafold AI - Kindly Requesting Feedback
Added 2025-02-06 10:50:21 +0000 UTCComing soon: a video all about alphafold and protein structures!
We'd love to hear your feedback and suggestions as we wrap up this video.
Animations are still in progress and pictures are used in place of videos at times.
Is there anything wrong? Any other questions? Anything more you'd like to see? Explanations you think don't do a good enough job or lack depth? Let us know!
Thank you so much for your time and help!
-Team Ve
Comments
Pretty dope video just could use your snazzy animation style.
Cameron Hicks
2025-03-14 01:16:49 +0000 UTCThis is excellent and loved the content. Nothing to add on the preview. Just finished Ray Kurzweil’s book The Singularity is Nearer where he also mentions this work and the accelerating pace of discovery. It will be amazing to see what will be learned in the next decade. Great job and excellent interviews.
Tony Winter
2025-02-10 08:53:04 +0000 UTCAmazing story, great overview, but so much more to cover. This is a good start. I would like to see more to help me understand the details a little better, like what are the rules of thumb of folding. Walking through a folding sequence might be helpful, what folds where and why.
Tom LaFleur
2025-02-08 13:51:01 +0000 UTCI will never get tired of this story. So cool and inspiring! Some of the nitty gritty about how alphafold 2 works was really fascinating, like what Dr. Kathryn had to say. Also, I've never heard of RF diffusion until now and I can't believe there isn't more attention on it! De novo protein synthesis is wild.
Stephen Woo
2025-02-08 02:44:37 +0000 UTCThere are proteins that have two stable folds, the so called fold-switching proteins. And as far as I know AlphaFold2 is actually not good at predicting structures of such proteins. See https://doi.org/10.1002/pro.4353 As to the presentation, in my opinion: it will be too hard to understand for a layman. One needs a bit more systematic and visual introduction into peptide chains: (1) snatoms are not good enough, a picture would be more informative (2) how the chains are fold themselves into secondary structures first and then into tertiary structures. Maybe you should also spend few seconds explaining that some proteins can be unfolded and then folded back, that misfolded proteins can lead to diseases, etc. That should keep people watching and trying to follow the story.
Oleg Obolensky
2025-02-07 03:30:06 +0000 UTCI like it, a lot. But have nothing to add or criticize :)
Pete Magill
2025-02-07 02:16:22 +0000 UTCGood stuff, wish I could say you missed this or that but you are explaining things I know very little about. Thanks.
Kat Seibert
2025-02-06 23:15:47 +0000 UTCDang ! More exciting than "Die Hard 14" !
Paul Weiss
2025-02-06 15:25:19 +0000 UTCWatched the rest. I think the main points are well presented for informed watchers, and am not up to date enough to comment on the latest developments. Good job.
Poker Chen
2025-02-06 11:57:03 +0000 UTCWatched 1 minute and had to stop: I think you have the wrong stereoisomer, at the carbon. You should swap the empty spot and the hydrogen atom around, and flip the Snatoms over so that the spot remains on top.
Poker Chen
2025-02-06 11:09:49 +0000 UTC
